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You are here:Home » Antibodies » Abs to Enzymes, Methyltransferase » Anti -Thiopurine S Methyltransferase (TPMT)

Anti -Thiopurine S Methyltransferase (TPMT)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B
TPMT (thiopurine S-methyltransferase) is an enzyme that catalyzes the S-methylation of aromatic and heterocyclic sulfhydryl compounds, including the immunosuppressant azathioprine (AZA) and the antineoplastic agents 6-mercaptopurine (6MP) and 6-thioguanine (6TG). This enzyme is also involved in the normal metabolic inactivation of thiopurine drugs. Patients with intermediate or no TPMT activity are at risk of toxicity after receiving standard doses of thiopurine drugs.
Catalog #T5009-95A
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionELISA: 0.05-0.2ug/ml
Western Blot: 0.5-1ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute by adding sterile sterile 40-50% glycerol, ddH2O. Reconstituted product is stable for 12 months at -20ºC. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a lyophilized powder from PBS, pH 7.4, 0.02% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide from amino terminal of human TPMT protein (Swiss Prot: P51580).(KLH coupled)
SpecificityRecognizes human TPMT protein.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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