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You are here:Home » Antibodies » Abs to Enzymes, Methyltransferase » Anti -Thiopurine S Methyltransferase (TPMT)

Anti -Thiopurine S Methyltransferase (TPMT)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified
TPMT (thiopurine S-methyltransferase) is an enzyme that catalyzes the S-methylation of aromatic and heterocyclic sulfhydryl compounds, including the immunosuppressant azathioprine (AZA) and the antineoplastic agents 6-mercaptopurine (6MP) and 6-thioguanine (6TG). The enzyme is also involved in the normal metabolic inactivation of thiopurine drugs. Patients with intermediate or no TPMT activity are at risk of toxicity after receiving standard doses of thiopurine drugs.
Catalog #T5009-95B
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionELISA: 0.05-0.2ug/ml
Western Blot: 0.5-1ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Reconstitute with sterile 40-50% glycerol, aliquot and store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a lyophilized powder in PBS, pH 7.4, 0.02% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide (KLH). within residues 200-250 of human TPMT protein (Swiss Prot: P51580).
SpecificityRecognizes human TPMT protein.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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