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You are here:Home » Antibodies » Abs to Enzymes, Methyltransferase » Anti -TPMT (Thiopurine S-methyltransferase, Thiopurine methyltransferase)

Anti -TPMT (Thiopurine S-methyltransferase, Thiopurine methyltransferase)

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified E
This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals. A pseudogene for this locus is located on chromosome 18q. [provided by RefSeq]
Catalog #T5009-95E
ApplicationsSuitable for use in ELISA. Other applications not tested.
Recommended DilutionELISA: 1:16,000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
HostGoat
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to C-DAFEERHKSWGID, from TPMT, at C-terminal (NP_000358.1).
SpecificityRecognizes TPMT. Species sequence homology: Bovine, canine, human, mouse and rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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