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You are here:Home » Antibodies » Abs to Thioredoxin » Anti -Thioredoxin 2 (Thioredoxin, Mitochondrial, Trx2, Mt-Trx, MTRX, Thioredoxin-2, TXN2, TRX2)

Anti -Thioredoxin 2 (Thioredoxin, Mitochondrial, Trx2, Mt-Trx, MTRX, Thioredoxin-2, TXN2,
TRX2)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Ascites IP
Thioredoxins (Trx) are small, multi-functional proteins with oxidoreductase activity and are ubiquitous in essentially all living cells. Trx contains a redox-active disulfide/ dithiol group within the conserved Cys-Gly-Pro-Cys active site. The two cysteine residues in the conserved active centers can be oxidized to form intramolecular disulfide bonds. Reduction of the active site disulfide in oxidized Trx is catalyzed by Trx reductase with NADPH as the electron donor. The reduced Trx is a hydrogen donor for ribonucleotide reductase, the essential enzyme for DNA synthesis, and a potent general protein disulfide reductase with numerous functions in growth and redox regulations. Specific protein disulfide targets for reduction by Trx include protein disulfide-isomerase (PDI) and a number of transcription factors such as p53, NF-kB and AP-1 (T1-151). Trx is also capable of removing H2O2, particularly when it is coupled with either methionine sulfoxide reductase or several isoforms of peroxiredoxins.
Catalog #T5010-15B
ApplicationsSuitable for use in Immunoprecipitation. Other applications not tested.
Recommended DilutionImmunoprecipitation: 2ul/400ul lysates
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG2b, k
Clone No10K369
HostMouse
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid.
PurityAscites
ImmunogenRecombinant human protein purified from E.coli.
SpecificityRecognizes human Thioredoxin 2. Species Crossreactivity: mouse, rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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