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You are here:Home » Antibodies » Abs to Thioredoxin » Anti -Thioredoxin Reductase 2 (Thioredoxin Reductase 2, Mitochondrial, Selenoprotein Z, SelZ, TR-beta, Thioredoxin Reductase TR3, TXNRD2, KIAA1652, TRXR2)

Anti -Thioredoxin Reductase 2 (Thioredoxin Reductase 2, Mitochondrial, Selenoprotein Z,
SelZ, TR-beta, Thioredoxin Reductase TR3, TXNRD2, KIAA1652, TRXR2)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified B IH
Thioredoxin Reductase 2 is a 56kD, ubiquitously expressed, mitochondrial selenoprotein and member of the class-I pyridine nucleotide-disulfide oxidoreductase family of proteins. Human TRXR2 is synthesized as a 524aa precursor that contains a 36aa transit peptide and a 488aa mature chain. A selenocysteine residue at position 523 is essential for enzymatic activity. Alternate splicing produces four isoforms. Human TRXR2 shares 86-85aa identity with mouse and rat TRXR2, respectively. TRXR2 maintains thioredoxin in a reduced state and is implicated in the defense against oxidative stress. It may also play a role in redox-regulated cell signaling.
Catalog #T5010-16E
ApplicationsSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 0.1ug/ml
Immunohistochemistry: 8-25ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG2B
Clone No11n189
HostMouse
SourceHuman
ConcentrationNot determined
FormSupplied as a lyophilized powder in PBS, trehalose. Reconstitute with sterile PBS to 0.5mg/ml.
PurityPurified by Protein A/G affinity chromatography.
ImmunogenRecombinant corresponding to aa268-393 human Thioredoxin Reductase 2 expressed in E. coli (Q9NNW73).
SpecificityRecognizes human Thioredoxin Reductase 2. Does not react with recombinant mouse TRXR2, recombinant human TRXR1, rhTRXR3.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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