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You are here:Home » Antibodies » Antibodies-Thrombopoietin » Anti -Thrombopoietin Receptor (TPO-R, Myeloproliferative Leukemia Protein, Proto-oncogene c-Mpl, CD110, TPOR) (PE)

Anti -Thrombopoietin Receptor (TPO-R, Myeloproliferative Leukemia Protein, Proto-oncogene
c-Mpl, CD110, TPOR) (PE)


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Clone Host Grade Applications
Monoclonal Mouse Affinity Purified FC
Thrombopoietin receptor (Tpo R), also known as myeloproliferative leukemia protein (c-mpl), is a 95kD type I transmembrane protein that is a member of the type I cytokine receptor family within the hematopoietin/cytokine receptor superfamily.1-4 The 635aa full-length human Tpo R contains a 25aa signal sequence, a 466aa extracellular domain with a ligand binding domain and two fibronectin type III domains, a transmembrane (TM) domain and a cytoplasmic domain. The extracellular domain of human Tpo R shares 78%, 76%, 81%, 82% and 80% aa identity with mouse, rat, cow, dog, and horse, respectively.
Catalog #T5050-50B
ApplicationsSuitable for use in Flow Cytometry. Other applications not tested.
Recommended DilutionsFlow Cytometry: 10ul labels 1x10e6 cells using TF-1 human erythroleukemic cell line.
Optimal dilutions to be determined by the researcher.
Storage and StabilityStore product at 4°C in the dark. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Clone TypeMonoclonal
Clone No11D72
FormSupplied as a liquid in saline, 0.5% BSA, 0.09% sodium azide. Labeled with R-Phycoerythrin (PE).
PurityPurified by Protein A affinity chromatography.
ImmunogenRecombinant protein corresponding to aa25-423 of human Thrombopoetin receptor expressed in NS0 cells (P40238).
SpecificityRecognizes human Thrombopoietin R. No crossreactivity with recombinant mouse Thrombopoietin R or recombinant human Erythropoietin R.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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