Anti -Thrombospondin (THBS, TSP, Thrombospondin 1, THBS1, THBS-1, Tsp1, Tsp-1)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Purified |
IH |
|
| Thrombospondin-1 is a 450kD trimeric glycoprotein first described in 1971. The molecule is stored in high concentrations in the alpha granules of platelets, constitutes 25% of platelet-secreted protein, and participates in platelet aggregation and clot formation. It is one of a class of adhesive glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. Numerous biological activities have been ascribed to TSP-1, including effects on cell adhesion, migration, proliferation, and angiogenesis. It also plays both complex and controversial role in tumor progression. | | | Catalog # | T5100-06Q | | Applications | Suitable for use in Immunohistochemistry. Other applications not tested. | | Recommended Dilution | Immunohistochemistry (formalin fixed paraffin embedded): 1:25-1:50 | | Optimal dilutions to be determined by the researcher. | | Positive Control | Tonsil | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG1 | | Clone No | 11E355 | | Host | Mouse | | Source | Human | | Concentration | As reported | | Form | Supplied as a liquid, 0.05% sodium azide. | | Purity | Purified | | Immunogen | Reduced and alkylated purified human TSP (fully denatured) from the supernatant of thrombin-activated platelets. Cellular Localization: Secretory granules, Golgi complex, endoplasmic reticulum. | | Specificity | Recognizes human Thrombospondin. Species Crossreactivity: bovine, canine, equine, mouse, porcine, rat, sheep. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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