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Anti -Thymic Stromal Lymphopoietin Protein Receptor (Cytokine Receptor-Like 2, TSLP-R)
Anti -Thymic Stromal Lymphopoietin Protein Receptor (Cytokine Receptor-Like 2, TSLP-R)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
B IH IF |
|
| Thymic stromal lymphopoietin (TSLP) has recently been identified as an important factor capable of driving dendritic cell maturation and activation. It is involved in the positive selection of regulatory T cells, maintenance of peripheral CD4+ T cell homeostasis and the induction of CD4+ T cell-mediated allergic reaction. TSLP is also capable of supporting the growth of fetal liver and adult B cell progenitors and their differentiation to the IgM-positive stage of B cell development. Its receptor TSLP-R will bind TSLP in a low-affinity fashion in transfected cells; cotransfection with IL-7R-alpha cDNA results in high-affinity binding and a functional heteromeric complex. This heteromeric receptor requires stat5 for TSLP-mediated signal transduction and is inhibited by SOCS-1. Despite its predicted molecular weight, TSLP-R often migrates at a higher molecular weight in SDS-PAGE. | | | Catalog # | T5150-07 | | Applications | Suitable for use in Western Blot, Immunofluorescence and Immunohistochemistry. Other applications not tested. | | Recommended Dilutions | Western Blot: 0.5-2ug/ml | | Immunofluorescence: 20ug/ml | | Immunohistochemistry: 5ug/ml | | Optimal dilutions to be determined by the researcher. | | Positive Control | Human liver tissue lysate | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | ~1mg/ml | | Form | Supplied as a liquid in PBS, 0.02% sodium azide. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Synthetic peptide corresponding to19aa near the center of human TSLP-R. (GenBank accession: Q9HC73). | | Specificity | Recognizes human TSLP-R. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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