Login

Forgot your password?
New User?
Remember me
banner banner

You are here:Home » Antibodies » Abs to Enzymes, Synthetase » Anti -Thymidylate Synthase (Thymidylate Synthetase, TMS, TS, TSase, TYMS, TYMS Protein, Tyms Thymidylate Synthetase, dTMP Synthase, EC 2.1.1.45, HsT422, MGC88736) (Azide Free)

Anti -Thymidylate Synthase (Thymidylate Synthetase, TMS, TS, TSase, TYMS, TYMS Protein,
Tyms Thymidylate Synthetase, dTMP Synthase, EC 2.1.1.45, HsT422, MGC88736) (Azide Free)

Pricing

  For pricing information, USA customers sign in.
  Outside USA? Please contact your distributor for pricing.

Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified B IF
Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase.
Catalog #T5155-10D
ApplicationsSuitable for use in Immunofluorescence (IC) and Western Blot. Other applications not tested.
Recommended DilutionsWestern Blot: 1:500-1:1000
Optimal dilutions to be determined by the researcher.
HybridomaSp2/0 myeloma cells with spleen cells from Balb/c mice.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1
Clone No10B2490
HostMouse
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS, pH 7.2. No preservative added (Azide free).
PurityPurified by Protein A affinity chromatography.
ImmunogenPartial recombinant protein corresponding to a portion of amino acids within aa111-211 from human Thymidylate synthase, GST tag. MW of the GST tag alone is 26kD (P04818).
SpecificityRecognizes human Thymidylate synthase.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


External Links