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You are here:Home » Antibodies » Abs to Transcription Factors, Homeobox (HOX) » Anti -Thyroid Transcription Factor 1 (TTF-1, Thyroid nuclear factor 1, Homeobox protein Nkx-2.1)

Anti -Thyroid Transcription Factor 1 (TTF-1, Thyroid nuclear factor 1, Homeobox protein
Nkx-2.1)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Ascites IH IC IF
TTF-1 (38kD) is a member of the Nkx2 family of homeodomain-containing transcription factors. TTF-1 has been identified as a mediator of thyroid-specific gene transcription, and is involved in the activation of pulmonary-specific genes.2 TTF-1 is expressed in the epithelial cells of the lung and thyroid gland. TTF-1 is useful as part of a panel of antibodies used to differentiate lung and thyroid primary carcinomas from other carcinomas that metastasize to the lung such as breast and colon carcinomas3. It may also be useful as part of a panel of antibodies, including anti-calretinin, used to differentiate primary lung adenocarcinomas from mesotheliomas.4
Catalog #T5405-02
ApplicationsSuitable for use in Immunofluorescence, Immunocytochemistry and Immunohistochemistry (frozen and paraffin sections, after microwave pretreatment). Tumors Specifically Detected: Useful in the classification of thyroid and lung tumors.
Recommended DilutionImmunohistochemistry: 1:10-1:20
Optimal dilutions to be determined by the researcher.
Positive ControlNormal thyroid or lung
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Store at -20°C or colder. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG1
Clone No5F143
HostMouse
ConcentrationNot determined
FormSupplied as a liquid.
PurityAscites
ImmunogenRat TTF-1 recombinant protein.
SpecificityReactive with human and rat. Recognizes a 40kD protein, identified as thyroid transcription factor 1 (TTF-1), selectively expressed in the lung, thyroid and diencephalon. The antigen has been localized in the nucleus. Tumors Specifically Detected: Useful in the classification of thyroid and lung tumors.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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