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You are here:Home » Antibodies » Abs to RNA Processing » Anti -TIA1 (TIA 1, TIA-1, TIA1 Protein, Cytotoxic Granule-associated RNA Binding Protein, Nucleolysin TIA1 isoform p40, Nucleolysin TIA-1 Isoform p40, p40 TIA-1, RNA Binding Protein TIA1, RNA Binding Protein TIA-1, TIA-1 Cytotoxic Granule-associated RNA Binding

Anti -TIA1 (TIA 1, TIA-1, TIA1 Protein, Cytotoxic Granule-associated RNA Binding Protein,
Nucleolysin TIA1 isoform p40, Nucleolysin TIA-1 Isoform p40, p40 TIA-1, RNA Binding
Protein TIA1, RNA Binding Protein TIA-1, TIA-1 Cytotoxic Granule-associated RNA Binding

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified E B
The product encoded by this gene is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15kD protein that is thought to be derived from the carboxyl terminus of the 40kD product by proteolytic processing. Alternative splicing resulting in different isoforms of this gene product has been described in the literature.
Catalog #T5461-95
ApplicationsSuitable for use in Peptide ELISA and Western Blot. Other applications not tested.
Recommended DilutionsPeptide ELISA: 1:128,000
Western Blot: 0.1-0.3ug/ml. Band of ~40kD was observed in lysates of Jurkat cell line. An additional band at 80kD and a very strong 26kD band was also observed. These bands were successfully blocked by incubation with the immunising peptide.
Optimal dilutions to be determined by the researcher.
Positive ControlJurkat cell lysate
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 
Clone TypePolyclonal
IsotypeIgG
HostGoat
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in Tris-saline, pH7.3, 0.5% BSA, 0.02% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to C-PKSTYESNTKQ of the internal region of human TIA1 (NP_071320.1; NP_071505.1).
SpecificityRecognizes human TIA1. Species Crossreactivity: mouse, rat and canine
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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