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Anti -TIM3 (Hepatitis A Virus Cellular Receptor 2, HAVcr-2, T-cell Immunoglobulin and Mucin Domain-containing Protein 3, TIMD-3, T-cell Membrane Protein 3, TIM-3, HAVCR2, TIMD3) (Carboxyfluorescein)
Anti -TIM3 (Hepatitis A Virus Cellular Receptor 2, HAVcr-2, T-cell Immunoglobulin and
Mucin Domain-containing Protein 3, TIMD-3, T-cell Membrane Protein 3, TIM-3, HAVCR2,
TIMD3) (Carboxyfluorescein)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Rat |
Affinity Purified |
FC |
|
| Mouse Tim-3 (T-cell Immunoglobulin- and Mucin -domain- containing molecule -3) is a type I transmembrane protein that contains an immunoglobulin V-type domain followed by a mucin-like domain in its extracellular region.1 Tim-3 is expressed on Th1 and Tc1 cells and is hypothesized to regulate macrophage activation.1 Binding of Tim-3 to Tim-3 Ligand on CD4+ T cells suggests that these proteins function in regulating Th1 cell expansion and/or activation,2 and suggests a role for Tim-3 in inducing tolerance.3 Mouse models utilizing antibodies to Tim-3 reveal a role for Tim-3 in immune-mediated diseases such as asthma and multiple sclerosis.2, 4 | | | Catalog # | T5469-92L | | Applications | Suitable for use in Flow Cytometry. Other applications not tested. | | Recommended Dilution | Optimal dilutions to be determined by the researcher. | | Hybridoma | Myeloma cells with B cells from Balb/c mice. | | Absorption | 488nm | | Emission | 515-545nm | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. CFS conjugates are sensitive to light. | | Clone Type | Monoclonal | | Isotype | IgG2A | | Clone No | 11n191 | | Host | Rat | | Source | Mouse | | Concentration | As reported | | Form | Supplied as a liquid in 1ml saline, 0.5% BSA, 0.1% sodium azide. Labeled with Carboxyfluorescein (CFS). | | Purity | Purified by Protein G affinity chromatography. | | Immunogen | Recombinant corresponding to aa20-193 from mouse TIM-3 expressed in NSO cells (Q8VIM0). | | Specificity | Recognizes mouse TIM-3. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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