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Anti -TIM4, ID (T-cell Immunoglobulin and Mucin Domain-containing Protein 4, TIMD-4, T-cell Membrane Protein 4, TIM-4, TIMD4)
Anti -TIM4, ID (T-cell Immunoglobulin and Mucin Domain-containing Protein 4, TIMD-4,
T-cell Membrane Protein 4, TIM-4, TIMD4)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Purified |
E B IC |
|
| The T cell immunoglobulin and mucin domain containing protein (TIM) family encodes cell surface receptors that are involved in the regulation of T helper (Th) -1 and –2 cell-mediated immunity. TIM-4, which is preferentially expressed on macrophages and dendritic cells, is the natural ligand of TIM-1, and this binding leads to T-cell expansion and cytokine production. Unlike other members of the TIM family, TIM-4 lacks a putative tyrosine phosphorylation signal sequence in its intracellular domain. The TIM-4 gene maps to a locus associated with predisposition to asthma in both mice and humans and with its connection to TIM-1-triggered Th2 responsiveness, may be considered as a candidate disease/predisposition gene for asthma. | | | Catalog # | T5469-93C | | Applications | Suitable for use in ELISA, Western Blot and Immunocytochemistry. Other applications not tested. | | Recommended Dilution | Western Blot: 1-2ug/ml | | Optimal dilutions to be determined by the researcher. | | Positive Control | Jurkat cell lysate | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | ~0.1mg/ml | | Form | Supplied as a liquid in PBS, 0.02% sodium azide. | | Purity | Purified | | Immunogen | Synthetic peptide corresponding to 16aa from near the center of human TIM-4. | | Specificity | Recognizes human TIM-4. Species Crossreactivity: mouse. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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