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You are here:Home » Antibodies » Abs to T Cells, Lymphocytes » Anti -TIM-4 (T-cell Immunoglobulin and Mucin Domain-containing Protein 4, TIMD-4, Spleen, Mucin-containing, Knockout of Lymphotoxin Protein, SMUCKLER, T-cell Membrane Protein 4, Timd4, Tim4)

Anti -TIM-4 (T-cell Immunoglobulin and Mucin Domain-containing Protein 4, TIMD-4, Spleen,
Mucin-containing, Knockout of Lymphotoxin Protein, SMUCKLER, T-cell Membrane Protein 4,
Timd4, Tim4)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Hamster Affinity Purified E FC IF
TIMD-4 is a type I transmembrane protein belonging to the immunoglobulin superfamily, containing one Ig-like V-type (immunoglobulin-like) domain. TIMD-4 is expressed in Mac1+ cells in spleen, lymph nodes and fetal liver. TIMD-4 binds apoptotic cells by recognizing phosphatidylserine via its immunoglobulin domain. TIMD-4 in fibroblasts enhanced their ability to engulf apoptotic cells. TIMD-4 is involved in regulating T-cell proliferation and lymphotoxin signaling. TIMD-4 and TIMD-1 are phosphatidylserine receptors for the engulfment of apoptotic cells, and are also involved in intracellular signaling in which exosomes are involved. This monoclonal antibody blocks the engulfment of apoptotic cells by thymic macrophages.
Catalog #T5469-94
ApplicationsSuitable for use in Flow Cytometry, ELISA, Functional Studies and Immunofluorescence. Not suitable for use in Immunohistochemistry and Western Blot. Other applications not tested.
Recommended DilutionFlow Cytometry: 1:50
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG
Clone NoKat5-18
HostHamster
SourceMouse
Concentration~0.1mg/ml
FormSupplied as a liquid in PBS, 0.1% BSA.
PurityPurified by Protein G affinity chromatography.
ImmunogenMouse peritoneal cells
SpecificityRecognizes mouse TIM-4. Blocks the engulfment of apoptotic cells by thymic macrophages (ref. 1).
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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