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You are here:Home » Antibodies » Abs to Circadian Proteins » Anti -Timeless (TIMELESS, TIM, hTIM, Timeless 1, Timeless1, TIM1)

Anti -Timeless (TIMELESS, TIM, hTIM, Timeless 1, Timeless1, TIM1)

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Specifications

Clone Host Grade Applications
Monoclonal Rabbit Supernatant B FC
Timeless is required for normal progression of S-phase, and is involved in the circadian rhythm autoregulatory loop. It natively regulates CLOCK-NPAS2/BMAL1-induced transactivation of PER1 possibly via translocation of PER1 into the nucleus. Timeless is also involved in cell survival after DNA damage or replication stress. It is specifically required for the ATR-CHK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light. Timeless plays an important role in epithelial cell morphogenesis and formation of branching tubules (1).
Catalog #T5470-04C
ApplicationsSuitable for use in Western Blot and Flow cytometry. Other applications have not been tested.
Recommended Dilutions
Western Blot: 1:1000-1:10,000
Flow cytometry: 1:10-1:100
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Manufactured incorporating RabMAb® technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
Clone TypeMonoclonal
Clone NoEPR5274(2)
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid in PBS, pH 7.2, 0.05% BSA, 0.01% sodium azide, 50% glycerol.
PuritySupernatant
ImmunogenSynthetic peptide corresponding to residues near the N-terminus of human Timeless.
SpecificityRecognizes human Timeless. Species crossreactivity: Mouse, rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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