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You are here:Home » Antibodies » Abs to RNA Processing » Anti -TIA1 (Cytotoxic Granule-associated RNA binding protein, Nucleolysin TIA-1 isoform p40, p40-TIA-1, T-cell-restricted intracellular antigen-1, RNA-binding protein)

Anti -TIA1 (Cytotoxic Granule-associated RNA binding protein, Nucleolysin TIA-1 isoform
p40, p40-TIA-1, T-cell-restricted intracellular antigen-1, RNA-binding protein)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Supernatant IH
TIA-1 (T-cell intracytoplasmic antigen) monoclonal antibody reacts with a 15kD cytoplasmic granule-associated protein, expressed in lymphocytes processing cytolytic potential. The expression of TIA-1 was studied in CD30+ anaplastic large cell lymphomas (ALCL), NK cell lymphomas and peripheral T-cell lymphomas and T cell lymphocytosis, B-cell lymphomas and lymphoblastic leukemia, Hodgkins, etc. Studies showed that 60 to 70% of anaplastic large cell lymphoma reacted with TIA-1. Studies also indicate that TIA-1 reacts with most large granular lymphocytic leukemias, hepatosplenic T-cell lymphomas, intestinal T-cell lymphomas, NK-like T-cell lymphomas, NK-cell lymphomas, nasal T/NK-cell lymphomas, subcutaneous T-cell lymphomas, pulmonary angiocentric lymphomas of T or NK phenotype. The authors concluded from TIA-1 studies that anaplastic large-cell lymphomas are cytotoxic T-or NK-cell neoplasms. All B-cell lymphomas, Hodgkins and lymphoblastic leukemias were negative for TIA-1 (1).
Catalog #T5498-45
ApplicationsSuitable for use in Immunohistochemistry. Other applications not tested.
Recommended DilutionsImmunohistochemistry (paraffin): 1:50-1:100. Incubate for 30-60 minutes at RT. Use heat-mediated antigen retrieval; an optional pepsin treatment can also improve the signal.
Optimal dilutions to be determined by the researcher.
Positive Control  
Anaplastic large cell lymphoma or tonsil
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1
Clone No4i389
HostMouse
SourceHuman
ConcentrationNot Determined
FormSupplied as a liquid in proprietary buffer with protein carrier and sodium azide.
PuritySupernatant
ImmunogenRecombinant full length human TIA 1. Cellular localization:  
Cytoplasmic (granular).
SpecificityRecognizes human TIA 1.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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