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Anti -TIA1 (Cytotoxic Granule-associated RNA binding protein, Nucleolysin TIA-1 isoform p40, p40-TIA-1, T-cell-restricted intracellular antigen-1, RNA-binding protein)
Anti -TIA1 (Cytotoxic Granule-associated RNA binding protein, Nucleolysin TIA-1 isoform
p40, p40-TIA-1, T-cell-restricted intracellular antigen-1, RNA-binding protein)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Supernatant |
IH |
|
| TIA-1 (T-cell intracytoplasmic antigen) monoclonal antibody reacts with a 15kD cytoplasmic granule-associated protein, expressed in lymphocytes processing cytolytic potential. The expression of TIA-1 was studied in CD30+ anaplastic large cell lymphomas (ALCL), NK cell lymphomas and peripheral T-cell lymphomas and T cell lymphocytosis, B-cell lymphomas and lymphoblastic leukemia, Hodgkins, etc. Studies showed that 60 to 70% of anaplastic large cell lymphoma reacted with TIA-1. Studies also indicate that TIA-1 reacts with most large granular lymphocytic leukemias, hepatosplenic T-cell lymphomas, intestinal T-cell lymphomas, NK-like T-cell lymphomas, NK-cell lymphomas, nasal T/NK-cell lymphomas, subcutaneous T-cell lymphomas, pulmonary angiocentric lymphomas of T or NK phenotype. The authors concluded from TIA-1 studies that anaplastic large-cell lymphomas are cytotoxic T-or NK-cell neoplasms. All B-cell lymphomas, Hodgkins and lymphoblastic leukemias were negative for TIA-1 (1). | | | Catalog # | T5498-45 | | Applications | Suitable for use in Immunohistochemistry. Other applications not tested. | | Recommended Dilutions | Immunohistochemistry (paraffin): 1:50-1:100. Incubate for 30-60 minutes at RT. Use heat-mediated antigen retrieval; an optional pepsin treatment can also improve the signal. | | Optimal dilutions to be determined by the researcher. | | Positive Control | | | Anaplastic large cell lymphoma or tonsil | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG1 | | Clone No | 4i389 | | Host | Mouse | | Source | Human | | Concentration | Not Determined | | Form | Supplied as a liquid in proprietary buffer with protein carrier and sodium azide. | | Purity | Supernatant | | Immunogen | Recombinant full length human TIA 1. Cellular localization: | | Cytoplasmic (granular). | | Specificity | Recognizes human TIA 1. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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