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You are here:Home » Antibodies » Abs to Adapter Proteins » Anti -TICAM-1 (Toll-interleukin 1 Receptor Domain (TIR)-containing Adaptor Molecule-1, TRIF, Toll/IL-1 Receptor Domain-containing Adapter-inducing IFN-beta)

Anti -TICAM-1 (Toll-interleukin 1 Receptor Domain (TIR)-containing Adaptor Molecule-1,
TRIF, Toll/IL-1 Receptor Domain-containing Adapter-inducing IFN-beta)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Highly Purified B IH
TRIF is a member of the Toll/interleukin-1 receptor (TIR) family, a group of proteins that include the Toll-like receptors (TLRs) (1-3). TLRs are signaling molecules that recognize different pathogen-associated molecular patterns (PAMPs) and serve as an important link between the innate and adaptive immune responses (4). TRIF, along with other molecules such as TIRP, TIRAP, and MyD88, serves as an adaptor protein to several of the TLR molecules. Following activation of TLR3 and TLR4, TRIF engages the kinase TBK1 and allows its subsequent activation of the interferon regulatory factor (IRF)-3 (5). TRIF is also involved in the activation of TNF receptor associated factor (TRAF)-6, and ultimately the activation of NF-kB (6).
Catalog #T5498-52
ApplicationsSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutonsWestern Blot: 2-4ug/ml
Immunohistochemistry: 10ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, pH 7.2, 0.02% sodium azide.
PurityPurified by Ion Exchange chromatography.
ImmunogenSynthetic peptide corresponding to 14aa near the C-terminus of human TRIF. GenBank accession #NP_891549.
SpecificityRecognizes human TRIF (TICAM-1).
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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