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You are here:Home » Antibodies » Abs to Adapter Proteins » Anti -TICAM-1, CT (Ticam1, TIR Domain Containing Adaptor Inducing Interferon-beta, Toll-like Receptor Adaptor Molecule 1, B0L0T7, TICAM1 (2 of 2), trif, CH211-124A3.1-001)

Anti -TICAM-1, CT (Ticam1, TIR Domain Containing Adaptor Inducing Interferon-beta,
Toll-like Receptor Adaptor Molecule 1, B0L0T7, TICAM1 (2 of 2), trif, CH211-124A3.1-001)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B
TICAM-1 (TRIF) is a member of the Toll/interleukin-1 receptor (TIR) family, a group of proteins that include the Toll-like receptors (TLRs). TLRs are signaling molecules that recognize different pathogen-associated molecular patterns (PAMPs) and serve as an important link between the innate and adaptive immune responses. TICAM-1, along with other molecules such as TIRP, TIRAP, and MyD88, serves as an adaptor protein to several of the TLR molecules. Following activation of TLR3 and TLR4, TICAM-1 engages the kinase TBK1 and allows its subsequent activation of the interferon regulatory factor (IRF)-3. TICAM-1 is also involved in the activation of TNF receptor associated factor (TRAF)-6, and ultimately the activation of NF-kB. Study focused on the functional characterization of zebrafish TICAM-1 suggested that the full length cDNA of zebrafish TICAM-1 encodes a protein of 556aa; TICAM-1 is able to induce the IFN promoter as well as activate NF-kappaB response promoter.
Catalog #T5498-53
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionELISA: 1:5000-1:20,000
Western Blot: 1:500-1:1000
Optimal dilutions to be determined by the researcher.
Control Peptide T5498-53P
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceZebrafish
ConcentrationNot determined
FormSupplied as a liquid in 40mM MOPS, pH 7.5, 0.1% BSA, 0.05% sodium azide, 50% glycerol.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to the C-terminal region of zebrafish TICAM-1.
SpecificityRecognizes zebrafish TICAM-1.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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