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Abs to Toll Like Receptors (TLR)
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Anti -TIRAP (MAL, Toll-interleukin 1 Receptor Domain containing Adaptor Protein, TIRAP)
Anti -TIRAP (MAL, Toll-interleukin 1 Receptor Domain containing Adaptor Protein, TIRAP)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Purified |
B |
|
| The Toll-like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules (1). The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition (2). Ten human homologs of TLRs (TLR1-10) have been described (3). TIRAP (TIR domain-containing adaptor protein) is an adaptor protein used by TLR4. Blocking TIRAP inhibits TLR4-mediated signaling events, including DC maturation and cytokine production (4). It has 235 amino acids and is commonly seen as a 32-37 kD protein (4). | | | Catalog # | T5500 | | Applications | Suitable for use in Western Blot. Other applications not tested. | | Recommended Dilution | Western Blot: 1:100 | | observed size: 32 kD | | positive control: HUVEC cell lysate | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Freeze at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgM | | Clone No | 4H263 | | Host | Mouse | | Source | Human | | Concentration | As reported | | Form | Tissue culture supernatant containing 0.05% sodium azide. | | Purity | Purified | | Immunogen | Synthetic peptide corresponding to a portion of human TIRAP. | | Specificity | Recognizes human TIRAP (TIR Domain-containing Adaptor Protein) | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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