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You are here:Home » Antibodies » Abs to Toll Like Receptors (TLR) » Anti -TIRAP (TIR Domain-containing Adapter Protein, Toll Interleukin-1 Receptor (TIR) Domain-containing Adaptor Protein, Toll/interleukin-1 Receptor Domain-containing Adapter Protein, Toll-like Receptor Adaptor Protein, Adapter Protein Wyatt, FLJ42305, HGNC:171

Anti -TIRAP (TIR Domain-containing Adapter Protein, Toll Interleukin-1 Receptor (TIR)
Domain-containing Adaptor Protein, Toll/interleukin-1 Receptor Domain-containing Adapter
Protein, Toll-like Receptor Adaptor Protein, Adapter Protein Wyatt, FLJ42305, HGNC:171

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified E B
The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described.
Catalog #T5500-01C
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Positive Control K562 cell lysate
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20°C. Aliquots are stable for at least 3 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
HostGoat
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in Tris-saline, pH 7.2. 0.5% BSA, 0.02% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide: C-QTLLKKPKKRPNSPE, representing the internal region of the human protein according to NP_001034750.1; NP_683708.1.
SpecificitySpecies Crossreactivity: Human. Other species not tested.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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