Login

Forgot your password?
New User?
Remember me
banner banner

You are here:Home » Antibodies » Abs to Toll Like Receptors (TLR) » Anti -TIRAP, CT (Toll-interleukin 1 Receptor Domain Containing Adapter Protein, TIR Domain-containing Adapter Protein, Adaptor Protein Wyatt, MyD88 Adapter-like Protein, Mal, Tlr4ap)

Anti -TIRAP, CT (Toll-interleukin 1 Receptor Domain Containing Adapter Protein, TIR
Domain-containing Adapter Protein, Adaptor Protein Wyatt, MyD88 Adapter-like Protein, Mal,
Tlr4ap)

Pricing

  For pricing information, USA customers sign in.
  Outside USA? Please contact your distributor for pricing.

Specifications

Clone Host Grade Applications
Polyclonal Rabbit Purified B IH
Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. These proteins act through adaptor molecules such as TIRAP and MyD88 to activate various kinases and transcription factors. In TIRAP-deficient mice, TLR signaling in response to TLR2 ligands (using either TLR1 and TLR6 as co-receptors) is totally abolished, suggesting that MyD88 and TIRAP work together and are both required for TLR2 signaling. Furthermore, these mice are also resistant to the toxic effects of LPS and show defects in NF-?B and MAP kinase activation, suggesting that TIRAP is also involed in TLR4 signaling.
Catalog #T5500-01M
ApplicationsSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 0.5-2ug/ml
Immunohistochemistry (paraffin): 2ug/ml
Optimal dilutions to be determined by the researcher.
Positive ControlHuman heart cell lysates.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceMouse
ConcentrationAs reported
FormSupplied as a liquid in PBS, 0.02% sodium azide.
PurityPurified
ImmunogenSynthetic peptide corresponding to murine TIRAP (CT).
SpecificityRecognizes mouse TIRAP/Mal (CT). Species Crossreactivity: rat and human.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesToll-interleukin 1 Receptor (TIR) Domain-containing Adaptor Protein, AA407980, C130027E04Rik


External Links