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You are here:Home » Antibodies » Abs to Toll Like Receptors (TLR) » Anti -TIRAP (MAL, Toll-interleukin 1 Receptor Domain containing Adaptor Protein, TIRAP)

Anti -TIRAP (MAL, Toll-interleukin 1 Receptor Domain containing Adaptor Protein, TIRAP)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IH
Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. These proteins act through adaptor molecules such as TIRAP and MyD88 to activate various kinases and transcription factors. In TIRAP-deficient mice, TLR signaling in response to TLR2 ligands (using either TLR1 and TLR6 as co-receptors) is totally abolished, suggesting that MyD88 and TIRAP work together and are both required for TLR2 signaling. Furthermore, these mice are also resistant to the toxic effects of LPS and show defects in NF-kB and MAP kinase activation, suggesting that TIRAP is also involed in TLR4 signaling.
Catalog #T5500-02
ApplicationsSuitable for use in Western Blot. and Immunohistochemistry. Other applications not tested.
Recommended DilutionsWestern Blot: 0.5-2ug/ml
Immunohistochemistry: 2ug/ml
Optimal dilution determined by the researcher.
Recommended Secondary ReagentsSheep anti rabbit IgG: HRP
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceMouse
Concentration~1mg/ml
FormSupplied as a liquid in PBS, 0.02% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to 15aa near the C-terminus of mouse TIRAP (GenBank accession no. AAL05628).
SpecificityRecognizes mouse TIRAP. Species Crossreactivity: human, rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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