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You are here:Home » Antibodies » Abs to Matrix Metalloproteinases » Anti -Tissue Inhibitor of Metalloproteinases 1 (Erythroid Potentiating Activity, EPA, Collagenase Inhibitor, CI)

Anti -Tissue Inhibitor of Metalloproteinases 1 (Erythroid Potentiating Activity, EPA,
Collagenase Inhibitor, CI)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Purified E B IH
TIMP-1and TIMP-2 have similar properties, specifically in inhibiting enzymes of matrix metalloproteinase family, and are thought to be of great importance in the maintenance of connective tissue integrity. TIMP-1 forms a complex of 1:1 stoichiometry with activated interstitial collagenase, activated stromelysin, active form of 72kD Type IV collagenase (also known as MMP-2 or gelatinase A), and latent and active forms of 92kD Type IV collagenase (also known as MMP-9 or gelatinase B). TIMPs inhibit the proteolytic invasiveness of tumor cells and normal placental trophoblast cells.
Catalog #T5580-15
ApplicationsSuitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications have not been tested.
Recommended DilutionsWestern Blot: 5-10ug/ml. Recognizes a band at ~28-30kD in reduced samples.
Immunohistochemistry: 1ug/section
ELISA: 5ug/ml
Optimal dilution to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, 0.02% sodium azide.
PurityPurified
ImmunogenFull length purified human fibroblast TIMP (Tissue Inhibitor of Metalloproteinase).
SpecificityRecognizes human TIMP (Tissue Inhibitor of Metalloproteinase). Recognizes native and denatured TIMP and TIMP in and out of enzyme/inhibitor complex. Does not crossreact with other human proteins tested. Not known to inhibit biological activity.
Species CrossreactivityRabbit, sheep, bovine, rat, equine and ferret
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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