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Anti -Tissue Inhibitor of Metalloproteinases 1 (Erythroid Potentiating Activity, EPA, Collagenase Inhibitor, CI)
Anti -Tissue Inhibitor of Metalloproteinases 1 (Erythroid Potentiating Activity, EPA,
Collagenase Inhibitor, CI)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Purified |
E B IH |
|
| TIMP-1and TIMP-2 have similar properties, specifically in inhibiting enzymes of matrix metalloproteinase family, and are thought to be of great importance in the maintenance of connective tissue integrity. TIMP-1 forms a complex of 1:1 stoichiometry with activated interstitial collagenase, activated stromelysin, active form of 72kD Type IV collagenase (also known as MMP-2 or gelatinase A), and latent and active forms of 92kD Type IV collagenase (also known as MMP-9 or gelatinase B). TIMPs inhibit the proteolytic invasiveness of tumor cells and normal placental trophoblast cells. | | | Catalog # | T5580-15 | | Applications | Suitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications have not been tested. | | Recommended Dilutions | Western Blot: 5-10ug/ml. Recognizes a band at ~28-30kD in reduced samples. | | Immunohistochemistry: frozen sections | | ELISA: 5ug/ml | | Optimal dilution to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | ~1mg/ml | | Form | Supplied as a liquid in PBS, 0.02% sodium azide. | | Purity | Purified | | Immunogen | Full length purified human fibroblast TIMP (Tissue Inhibitor of Metalloproteinase). | | Specificity | Recognizes human TIMP (Tissue Inhibitor of Metalloproteinase). Recognizes native and denatured TIMP and TIMP in and out of enzyme/inhibitor complex. Does not crossreact with other human proteins tested. Not known to inhibit biological activity. | | Species Crossreactivity | Rabbit, sheep, bovine, rat, equine and ferret | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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