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You are here:Home » Antibodies » Abs to Toll Like Receptors (TLR) » Anti -TLR1 (Toll Like Receptor 1)

Anti -TLR1 (Toll Like Receptor 1)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B FC
The Toll-like receptor (TLR) family in mammals are comprised of a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and an IL-1 receptor motif in the cytoplasmic domain. The TLRs could constitute an important and unrecognized component of innate immunity in humans. In mice, TLR1 interacts with TLR2 and coexpression of TLR1 and TLR2 enhance the NF-kappaB activation in response to a synthetic lipopeptide. They recognize the lipid configuration of the native mycobacterial lipoprotein as well as several triacylated lipopeptides.
Catalog #T8050-03
ApplicationsSuitable for use in Western Blot and Flow Cytometry. Other applications not tested.
Recommended DilutionWestern Blot: 1-3ug/ml
Flow Cytometry: 2-4ug/1x10e6 cells
Optimal dilutions to be determined by the researcher.
Recommended Positive Control
Ramos cell lysate (87kD)
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in PBS, 0.2% gelatin, 0.05% sodium azide.
PurityPurified by Protein G affinity chromatography.
ImmunogenSynthetic peptide corresponding to a sequence within aa400-450 of human TRL1 (KLH coupled).
SpecificityRecognizes human TRL1. Does not cross-react with mouse TLR1.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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