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Specifications

Clone Host Grade Applications Polyclonal Rabbit Affinity Purified B FC

The Toll-like receptor (TLR) family in mammals are comprised of a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and an IL-1 receptor motif in the cytoplasmic domain. The TLRs could constitute an important and unrecognized component of innate immunity in humans. In mice, TLR1 interacts with TLR2 and coexpression of TLR1 and TLR2 enhance the NF-kappaB activation in response to a synthetic lipopeptide. They recognize the lipid configuration of the native mycobacterial lipoprotein as well as several triacylated lipopeptides.
Catalog #	T8050-03
Applications	Suitable for use in Western Blot and Flow Cytometry. Other applications not tested.
Recommended Dilution	Western Blot: 1-3ug/ml
	Flow Cytometry: 2-4ug/1x10e6 cells
	Optimal dilutions to be determined by the researcher.
Recommended Positive Control
	Ramos cell lysate (87kD)
Storage and Stability	May be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
CAS Number	n/a
Clone Type	Polyclonal
Isotype	IgG
Host	Rabbit
Source	Human
Concentration	~0.5mg/ml
Form	Supplied as a liquid in PBS, 0.2% gelatin, 0.05% sodium azide.
Purity	Purified by Protein G affinity chromatography.
Immunogen	Synthetic peptide corresponding to a sequence within aa400-450 of human TRL1 (KLH coupled).
Specificity	Recognizes human TRL1. Does not cross-react with mouse TLR1.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.