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Anti -TLR2 (Toll Like Receptor 2, CD282)
Anti -TLR2 (Toll Like Receptor 2, CD282)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Affinity Purified |
E IH FC |
|
| Toll-like receptors (TLR) are highly conserved throughout evolution and have been implicated in the innate defense to many pathogens. In Drosophila toll is required for the anti-fungal response, while the related 18-wheeler is involved in antibacterial defenses. In mammals, TLR identified as type I transmembrane signaling receptors with pattern recognition capabilities, have been implicated in the innate host defense to pathogens. TLR2 has been identified as a receptor | | | that is central to the innate immune response to lipoproteins of gram-negative bacteria, several whole gram-positive bacteria, as well as a receptor for peptidoglycan and lipoteichoic acid and other bacterial cell membrane products. A functional interaction between TLR2 and TLR6 in the cellular response to various bacterial products has been discovered. The currently accepted paradigm regards TLR2 as an essential receptor for many eubacterial cell wall components, including lipoproteins and peptidoglycan. Bacterial species as diverse as mycobacteria, | | | spirochetes, mycoplasma, Staphylococcus aureus, and Streptococcus pneumoniae have all been shown to mediate cellular activation via TLR2. | | | Catalog # | T8050-09N | | Applications | Suitable for use in ELISA, Immunohistochemistry and Flow Cytometry. Not suitable for use in Western Blot or Immunoprecipitation. Other applications not tested. | | Recommended Dilutions | Immunohistochemistry: 1:50 | | Flow Cytometry: 1:50 | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG2b | | Clone No | 9G272 | | Host | Mouse | | Source | Mouse | | Concentration | ~0.1mg/ml | | Form | Supplied as a liquid in PBS, 0.1% BSA. | | Purity | Purified by Protein G affinity chromatography. | | Immunogen | Mouse TLR2 peptide | | Specificity | Recognizes mouse TLR2. Reacts with native TLR2 and does not react with denatured TLR2. Stains overexpressed, as well as endogenous cell surface- and intracellular mouse TLR2. Inhibits murine TLR2-mediated cell activation. Masks the lipopeptide binding site in the recombinant extracellular domain of TLR2 and does not hinder the receptor complex formation. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. | | Alternate names | TLR2, CD282 |
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