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You are here:Home » Antibodies » Abs to Toll Like Receptors (TLR) » Anti -TLR2 (Toll Like Receptor 2, Toll-like Receptor 2 Precursor, TLR 2, TLR-2, CD282, CD282 Antigen, Toll/interleukin 1 Receptor-like 4, Toll/interleukin Receptor-like Protein 4, TIL4)

Anti -TLR2 (Toll Like Receptor 2, Toll-like Receptor 2 Precursor, TLR 2, TLR-2, CD282,
CD282 Antigen, Toll/interleukin 1 Receptor-like 4, Toll/interleukin Receptor-like Protein
4, TIL4)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
The Toll-like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules (1). The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition (2). Ten human homologs of TLRs (TLR1-10) have been described (3). TLR2 is differentially expressed in human cells. TLR2 is expressed in tonsils, lymph nodes, and appendices, activated B-cells in germinal centers. CD14+ monocytes expressed the highest level of TLR2 followed by CD15+ granulocytes, and CD19+ B-cells, CD3+ T-cells, and CD56+ NK cells did not express TLR2. The expression of TLR2 on different cell types are regulated by different immune response modifiers. For example, LPS, GM-CSF, IL-1, and IL-10 up regulates TLR2 whereas IL-4, IFN-gamma, and TNF down regulate TLR2 expression in monocytes (4).
Catalog #T8050-10N
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Positive Control bronchial epithelial cells or transfected human TLR2 cell lysate.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20°C. Aliquots are stable for at least 3 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormPBS containing 0.2% gelatin, 0.05% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenThis antibody was developed against a mixture of synthetic peptides containing amino acids 180-196, 353-370, and 473-489 of human TLR2.
SpecificityIn Imgenex's transfected human TLR2 cell lysate, a 90kD band is observed. This antibody has also been reported to work well in bronchial epithelial cells (UBH16E) and THP-1 cells. Species Crossreactivity: Human.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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