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Specifications

Clone Host Grade Applications Polyclonal Rabbit Highly Purified B

Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses (1-3). These proteins act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors such as Protein Kinase C (PKC) alpha/beta and NF-kB (4-6). TLR2 can form heterodimers with either TLR1 or TLR6, and as a heterodimer can recognize a variety of bacterial and mycoplasma lipoproteins respectively (7).
Catalog #	T8050-11
Applications	Suitable for use in ELISA, Western Blotting. Other applications not tested.
Recommended Dilution	Western blot: 0.5-2ug/ml. Despite its predicted molecular weight, TLR2 runs at ~100kD in SDS-PAGE.
	Optimal dilutions to be determined by the researcher.
Storage and Stability	May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Freeze at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
CAS Number	n/a
Clone Type	Polyclonal
Isotype	IgG
Host	Rabbit
Source	Human
Concentration	~1mg/ml
Form	Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide.
Purity	Purified by Ion Exchange chromatography.
Immunogen	Raised against a peptide corresponding to 14 amino acids near the amino terminus of human TLR2 (GenBank accession no. O60603)
Specificity	Recognizes human TLR2. Species Crossreactivity: Mouse.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.