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You are here:Home » Antibodies » Abs to Toll Like Receptors (TLR) » Anti -TLR2 (Toll Like Receptor 2, Toll-like Receptor 2 Precursor, TLR 2, TLR-2, CD282, CD282 Antigen, Toll/interleukin 1 Receptor-like 4, Toll/interleukin Receptor-like Protein 4, TIL4)

Anti -TLR2 (Toll Like Receptor 2, Toll-like Receptor 2 Precursor, TLR 2, TLR-2, CD282,
CD282 Antigen, Toll/interleukin 1 Receptor-like 4, Toll/interleukin Receptor-like Protein
4, TIL4)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified B IP IH FC
Toll-like receptors (TLR) are highly conserved throughout evolution and have been implicated in the innate defense to many pathogens. In Drosophila toll is required for the anti-fungal response, while the related 18-wheeler is involved in antibacterial defenses. In mammals, TLR identified as type I transmembrane signaling receptors with pattern recognition capabilities, have been implicated in the innate host defense to pathogens. TLR2 has been identified as a receptor that is central to the innate immune response to lipoproteins of Gram-negative bacteria, several whole Gram-positive bacteria, as well as a receptor for peptidoglycan and lipoteichoic acid and other bacterial cell membrane products. A functional interaction between TLR2 and TLR6 in the cellular response to various bacterial products has been discovered. The currently accepted paradigm regards TLR2 as an essential receptor for many eubacterial cell wall components, including lipoproteins and peptidoglycan. Bacterial species as diverse as mycobacteria, spirochetes, mycoplasma, Staphylococcus aureus, and Streptococcus pneumoniae have all been shown to mediate cellular activation via TLR2. The TL2.1 monoclonal antibody is specific for human Toll-like receptor 2 (TLR2). TL2.1 is a TLR2 function blocking antibody that is useful for studies on the role of TLR2 as a pattern recognition receptor in microbial products induced cytokine production by TLR2 bearing cells such as human peripheral blood mononuclear cells.
Catalog #T8050-11K
ApplicationsSuitable for use in Flow Cytometry, Western Blot, Immunoprecipitation and Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunohistochemistry: frozen, paraffin
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG2a
Clone NoTL2.1
HostMouse
SourceHuman
Concentration~0.1mg/ml
FormSupplied as a liquid in PBS, 0.02% sodium azide, 0.1% BSA.
PurityPurified by Protein G affinity chromatography.
ImmunogenHuman TLR2.
SpecificityRecognizes human TLR2.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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