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Abs to Toll Like Receptors (TLR)
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Anti -TLR3 (Toll Like Receptor 3, Toll-like Receptor 3, TLR 3, TLR-3, CD283, CD283 Antigen) (FITC)
Anti -TLR3 (Toll Like Receptor 3, Toll-like Receptor 3, TLR 3, TLR-3, CD283, CD283
Antigen) (FITC)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Affinity Purified |
FC |
|
| Toll-like receptors (TLR) are highly conserved throughout evolution and have been implicated in the innate defense to many pathogens. In Drosophila toll is required for the anti-fungal response, while the related 18-wheeler is involved in antibacterial defenses. In mammals, TLR identified as type I transmembrane signalling receptors with pattern recognition capabilities, have been implicated in the innate host defense to pathogens. As investigated so far all functional characterized TLR signal via the TLR/IL-1 receptor (IL-1R) pathway where recruitment of MyD88 seems to be essential. Viral replication within infected cells results in generation of dsRNA which can stimulate immune cells. Recent data show that TLR3 (CD283) acts as a receptor involved in the recognition of dsRNA, indicating a role for TLR3 in viral recognition and innate defense. | | | Catalog # | T8050-20K | | Applications | Can be used for intracellular Flow Cytometry. Other applications not tested. | | Recommended Dilution | Flow Cytometry: 1:10 | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. FITC conjugates are sensitive to light. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG1 | | Clone No | 9G280 | | Host | Mouse | | Source | Human | | Concentration | As reported | | Form | Supplied as a liquid in PBS, 1% BSA, 0.02% sodium azide. Labeled with fluorescein isothiocyanate (FITC). | | Purity | Purified. | | Immunogen | Human TLR3. | | Specificity | Recognizes human Toll-like receptor 3 (TLR3, CD283). Species crossreactivity: dog. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. | | Alternate names | Toll-like receptor 3, CD284 |
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