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Specifications

Clone Host Grade Applications Polyclonal Chicken Affinity Purified E B

This protein is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NFkB and the production of type I interferons. It may thus play a role in host defense against viruses.
Catalog #	T8050-23
Applications	Suitable for use in ELISA and Western Blot. Other applications not tested.
Recommended Dilution	Western Blot: 1:1000-1:2000
	Optimal dilutions to be determined by the researcher.
Storage and Stability	May be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
CAS Number	n/a
Clone Type	Polyclonal
Isotype	IgY
Host	Chicken
Source	Human
Concentration	As reported
Form	Supplied as a liquid in PBS, pH 7.2. No preservative added. Glycerol free.
Purity	Purified by immunoaffinity chromatography.
Immunogen	Synthetic peptide corresponding to aa401-600
Specificity	Recognizes human TLR3. Species Crossreactivity: Mouse and rat.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.