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Anti -TLR4 (Toll-like Receptor 4, CD284)
Anti -TLR4 (Toll-like Receptor 4, CD284)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
B IP IH FC N |
|
| TLR4 (Toll-like receptor 4) is a mammalian homologue of the Drosophila Toll protein. The human TLR4 is a 799-residue type-1 transmembrane protein. The extracellular domain has leucine-rich repeats and the intracellular domain is similar to that of the IL-1 receptor. TLR4 is a receptor for lipopolysaccharide (LPS). In mice that are genetically tolerant to endotoxin, mutations have been identified in the intracellular domain of TLR4 that abolish LPS responsiveness. TLR4 uses a mechanism similar to that of the IL-1 receptor for signal transduction that leads to activation of NF-kB. | | | Catalog # | T8050-29E | | Applications | Suitable for use in Neutralizing, Flow Cytometry, Western Blot, Immunoprecipitation and Immunohistochemistry. Other applications not tested. | | Recommended Dilution | Western Blot: 1:3000 | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Host | Rabbit | | Source | Human | | Concentration | ~1mg/ml | | Form | Supplied as a liquid in 0.05% sodium azide. | | Purity | Purified by Protein A affinity chromatography. | | Immunogen | Recombinant protein corresponding to aa6-169 in human TLR4 expressed in E. coli. | | Specificity | Reacts with the TLR4 protein. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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