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You are here:Home » Antibodies » Abs to Toll Like Receptors (TLR) » Anti -TLR4 (Toll Like Receptor 4, CD284) (FITC)

Anti -TLR4 (Toll Like Receptor 4, CD284) (FITC)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified B IP FC IF
Toll-like receptors (TLR) are highly conserved throughout evolution and have been implicated in the innate defense to many pathogens. In Drosophila toll is required for the anti-fungal response, while the related 18-wheeler is involved in antibacterial defenses. In mammals, TLR identified as type I transmembrane signaling receptors with pattern recognition capabilities, have been implicated in the innate host defense to pathogens. TLR4 (CD284) has been identified next to MD-2 and CD14 as a receptor that is central to the innate immune response to lipopolysaccharides (LPS) of Gram-negative bacteria.
Catalog #T8050-29G
ApplicationsSuitable for use in FLISA, Flow Cytometry, Functional Studies, Immunofluorescence, Immunoprecipitation and Western Blot. Other applications not tested.
Recommended DilutionFlow Cytometry: Use 10 ul of the neat solution to label 10e6 cells or 100 ul whole blood.
Optimal dilutions to be determined by the researcher.
Storage and StabilityFor long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. FITC conjugates are sensitive to light.
Clone TypeMonoclonal
IsotypeIgG2a
Clone No6A639
HostMouse
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS, 1% BSA, 0.02% sodium azide. Labeled with fluorescein isothiocyanate (FITC).
PurityPurified by Protein G affinity chromatography.
ImmunogenBa/F3 cells expressing TLR4
SpecificityRecognizes human TLR4 (CD284) that is associated with MD-2. TLR4 (CD284) is a function-blocking antibody that is useful for studies on the role of TLR4 (CD284) as a receptor for LPS induced cytokine production by TLR4 bearing cells. Species crossreactivity: canine, cynomolgus monkey, rhesus monkey and marmoset monkey.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesCD284, Toll-like receptor 5


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