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You are here:Home » Antibodies » Abs to Toll Like Receptors (TLR) » Anti -TLR4 (Toll-like Receptor 4, hToll, CD284)

Anti -TLR4 (Toll-like Receptor 4, hToll, CD284)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
TLR4 is an 839aa member of the Toll-like receptor (TLR) family of transmembrane proteins comprised of multiple copies of leucine rich repeats in the extracellular domain and a TIR domain. It is a widely studied, phylogenetically conserved, member playing a fundamental role in pathogen recognition and activation of innate immunity. Like its counterpart in Drosophila, TLR4 signals through adaptor molecules and mediates the production of cytokines necessary for the development of effective immunity. TLR4 belongs to the multi-protein complex of lipopolysaccharide (LPS) receptor, containing CD14, LY96 and TLR4, and is involved in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. This receptor is most abundantly expressed in placenta, spleen and in myelomonocytic subpopulation of the leukocytes. Defects in this protein have been associated with differences in LPS responsiveness.
Catalog #T8050-30C
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 0.5-2ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to aa650-700 of human TLR4.
SpecificityRecognizes human TLR4. Species Crossreactivity
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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