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Abs to Toll Like Receptors (TLR)
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Anti -TLR4 (Toll-like Receptor 4, hToll, CD284)
Anti -TLR4 (Toll-like Receptor 4, hToll, CD284)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
B FC |
|
| TLR4 (Toll-like receptor 4) is a mammalain homolog of the Drosophila toll protein. The human TLR4 is a type-1 transmembrane protein containing 799aa residues. The extracellular domain has leucine-rich repeats and the intracellular domain is similar to that of IL-1 receptor. TLR4 is a receptor for lipopolysaccharide (LPS). In mice that are genetically tolerant to endotoxin, mutations have been identified in the intracellular domain of TLR4 that abolish LPS responsiveness. TLR4 uses a mechanism similar to that of the IL-1 receptor for signal transduction that leads to activation of NF-kB. | | | Catalog # | T8050-30H | | Applications | Suitable for use in Flow Cytometry and Western Blot. Other applications not tested. | | Recommended Dilution | Western Blot: 0.5-4ug/ml | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | ~0.1mg/ml | | Form | Supplied as a liquid in PBS, pH 7.2, 1% BSA, 0.02% thimerosal, 50% glycerol. | | Purity | Purified by Protein A affinity chromatography. | | Immunogen | Recombinant protein corresponding to human TLR4. | | Specificity | Recognizes human TLR4. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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