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You are here:Home » Antibodies » Antibodies-Toll Like Receptors (TLR) » Anti -TLR4 (Toll Like Receptor 4, Toll-like Receptor 4 Precursor, TLR 4, ARMD10, CD284, CD284 Antigen, hToll, TOLL)

Anti -TLR4 (Toll Like Receptor 4, Toll-like Receptor 4 Precursor, TLR 4, ARMD10, CD284,
CD284 Antigen, hToll, TOLL)


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Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E B IP IH FC IF
Toll-like receptors (TLR) are highly conserved throughout evolution and have been implicated in the innate defense to many pathogens. In Drosophila toll is required for the anti-fungal response, while the related 18-wheeler is involved in antibacterial defenses. In mammals, TLR identified as type I transmembrane signaling receptors with pattern recognition capabilities, have been implicated in the innate host defense to pathogens. TLR4 has been identified next to MD-2 and CD14 as a receptor that is central to the innate immune response to lipopolysaccharides (LPS) of Gram-negative bacteria. The HTA125 monoclonal antibody reacts preferentially, especially in Flow Cytometry, with human TLR4 that is associated with MD-2. HTA125 is a TLR4 function-blocking antibody that is useful for studies on the role of TLR4 as a receptor for LPS induced cytokine production by TLR4 bearing cells. The antibody was shown to precipitate TLR4 (100kD).
Catalog #T8050-31G
ApplicationsSuitable for use in ELISA, Flow Cytometry, Functional Studies, Immunofluorescence, Immunohistochemistry, Immunoprecipitation and Western Blot. Other applications not tested.
Recommended DilutionImmunohistochemistry: Frozen sections
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
Clone NoHTA125
FormSupplied as a liquid in PBS, 0.02% sodium azide, 0.1% BSA.
PurityPurified by Protein G affinity chromatography.
ImmunogenHuman TLR4.
SpecificityRecognizes human TLR4. Species Crossreactivity: Canine, monkey.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesHomolog of Drosophila Toll, Toll (Drosophila) Homolog, Toll Endotoxin Hyporesponsiveness

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