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Anti -TLR4 (Toll Like Receptor 4, CD284) (Biotin)
Anti -TLR4 (Toll Like Receptor 4, CD284) (Biotin)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Affinity Purified |
E B IP FC IF |
|
| Toll-like receptors (TLR) are highly conserved throughout evolution and have been implicated in the innate defense to many pathogens. In Drosophila, toll is required for the anti-fungal response, while the related 18-wheeler is involved in antibacterial defenses. In mammals, TLR identified as type I transmembrane signaling receptors with pattern recognition capabilities, have been implicated in the innate host defense to pathogens. TLR4 has been identified next to MD-2 and CD14 as a receptor that is central to the innate immune response to lipopolysaccharides (LPS) of Gram-negative bacteria. | | | Catalog # | T8050-34F | | Applications | Suitable for use in Flow Cytometry, Functional Studies, ELISA, Immunofluorescence, Immunoprecipitation and Western Blot. Other applications have not been tested. | | Recommended Dilution | Flow Cytometry: 1:50 | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG2a | | Clone No | 6A639 | | Host | Mouse | | Source | Human | | Concentration | ~0.1mg/ml | | Form | Supplied as a liquid in PBS, pH 7.4, 0.1% BSA, 0.02% chloroacetamide. Labeled with Biotin. | | Purity | Purified by Protein G affinity chromatography. | | Immunogen | Human TLR4. | | Specificity | Recognizes human TLR4 (CD284) that is associated with MD-2. This clone is a TLR4 (CD284) function-blocking antibody that is useful for studies on the role of TLR4 (CD284) as a receptor for LPS induced cytokine production by TLR4 bearing cells. Species crossreactivity: canine, cynomolgus monkey, rhesus monkey and marmoset monkey. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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