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You are here:Home » Antibodies » Abs to Toll Like Receptors (TLR) » Anti -TLR4 (Toll-like Receptor 4, hToll, CD284) (FITC)

Anti -TLR4 (Toll-like Receptor 4, hToll, CD284) (FITC)

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Specifications

Clone Host Grade Applications
Monoclonal Rat Affinity Purified FC
The Toll-like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules (1). The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition (2). Ten human homologs of TLRs (TLR1-10) have been described (3). Among this family of receptors, TLR2 and TLR4 have been most studied. These studies have suggested that TLR2 and TLR4 may serve as potential main mediators of LPS signaling (4,5). The mouse TLR4 cDNA codes for a protein consisting of 835aa with approximate molecular weight of 90kD (6).
Catalog #T8050-34N
ApplicationsSuitable for use in Flow Cytometry. Other applications not tested.
Recommended DilutionFlow Cytometry: 0.5-2ug/10e6 cells
Optimal dilutions to be determined by the researcher.
Positive ControlMouse peritoneal cells
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. FITC conjugates are sensitive to light.
Clone TypeMonoclonal
IsotypeIgG2a,k
Clone No11E372
HostRat
SourceMouse
Concentration~0.5mg/ml
FormSupplied as a liquid in 10mM Tris, 150mM sodium chloride, 0.05% BSA, 0.05% sodium azide. Labeled with fluorescein isothiocyanate (FITC).
PurityPurified by Protein G affinity chromatography.
ImmunogenRecombinant corresponding to mouse TLR4, expressed in Ba/F3 cell line.
SpecificityRecognizes mouse TLR4. Species sequence homology: most mammals.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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