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You are here:Home » Antibodies » Abs to Toll Like Receptors (TLR) » Anti -TLR4/MD-2 Complex (Toll Like Receptor 4/MD-2, MD-2, Toll Like Receptor 4, TLR4)

Anti -TLR4/MD-2 Complex (Toll Like Receptor 4/MD-2, MD-2, Toll Like Receptor 4, TLR4)

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Specifications

Clone Host Grade Applications
Monoclonal Rat Affinity Purified E IP IH FC
Toll-like receptors (TLR) are highly conserved throughout evolution and have been implicated in the innate defense to many pathogens. In Drosophila toll is required for the anti-fungal response, while the related 18-wheeler is involved in antibacterial defenses. In mammals, TLR identified as type I transmembrane signaling receptors with pattern recognition capabilities, have been implicated in the innate host defense to pathogens. TLR4 has been identified next to MD-2 and CD14 as a receptor that is central to the innate immune response to lipopolysaccharides (LPS) of Gram-negative bacteria. The MTS510 monoclonal antibody reacts preferentially, especially in Flow Cytometry, with murine TLR4 that is associated with MD-2. MTS510 is a TLR4 function-blocking antibody that is useful for studies on the role of TLR4 as a receptor for LPS induced cytokine production by TLR4 bearing cells. The antibody was shown to coprecipitate MD-2 (30kD) with TLR4 (100kD).
Catalog #T8050-35C
ApplicationsSuitable for use in Flow Cytometry and Immunoprecipitation. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG2a
Clone NoMTS510
HostRat
SourceMouse
Concentration~0.1mg/ml
FormSupplied as a liquid in PBS, 0.02% sodium azide, 0.1% BSA.
PurityPurified by Protein G affinity chromatography.
ImmunogenMouse TLR4/MD-2 Complex.
SpecificityRecognizes mouse TLR4/MD-2 complex.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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