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You are here:Home » Antibodies » Abs to Toll Like Receptors (TLR) » Anti -TLR5 (Toll Like Receptor 5, Toll-like Receptor 5 Precursor, TLR 5, TLR-5, FLJ10052, MGC126430, MGC126431, Toll/interleukin 1 Receptor-like Protein 3, TIL3)

Anti -TLR5 (Toll Like Receptor 5, Toll-like Receptor 5 Precursor, TLR 5, TLR-5, FLJ10052,
MGC126430, MGC126431, Toll/interleukin 1 Receptor-like Protein 3, TIL3)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IC
Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses (1,2). The TLRs act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors (3) so the organism can respond to potential infection. TLR5 recognizes flagellin from both Gram-positive and Gram-negative bacteria and will cause the activation of NF-kB, leading to the activation of TNF-a and other cytokines (4). A common TLR5 stop codon polymorphism that disrupts TLR5 signaling is associated with susceptibility to Legionnairesí disease and demonstrates the importance of TLR5 in the innate immune response (5).
Catalog #T8050-43B
ApplicationsSuitable for use in Western Blot and Immunocytochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 1-2ug/ml
Immunocytochemistry: 10ug/ml
Optimal dilutions to be determined by the researcher.
Blocking PeptideT8050-43B1: TLR5, CT, Control Peptide (Toll Like Receptor 5, Toll/Interluekin-1 Receptor-Like Gene 3, TIL3)
Positive ControlTHP-1 cell lysate
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, pH 7.2, 0.02% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic TLR5 peptide of 15aa near the carboxy terminus of human TLR5 (GenBank accession no. NP_003259).
SpecificityRecognizes human TLR5. Species Crossreactivity: Mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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