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You are here:Home » Antibodies » Abs to Toll Like Receptors (TLR) » Anti -TLR7 (Toll Like Receptor 7, TLR-7, PRO285, UNQ248)

Anti -TLR7 (Toll Like Receptor 7, TLR-7, PRO285, UNQ248)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B FC
The Toll-like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules (1) and could constitute an important and unrecognized component of innate immunity in humans. The TRL family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition (2). TLRs characterized so far activate the MyD88/interleukin-1 receptor-associated kinase (IRAK) signaling pathway. Ten human homologs of TLRs (TLR1-10) have been described (3). Stimulation of the NFkB signaling pathway by TLR7 suggests that it plays a role in immune response.
Catalog #T8050-73
ApplicationsSuitable for use in Flow Cytometry and Western Blot. Other applications not tested.
Recommended DilutionFlow Cytometry: 2-5ug/1x10e6 (Intracellular staining).
Western Blot: 1-3ug/ml
Optimal dilutions to be determined by the researcher.
Positive Control Ramos or Raw cells
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in PBS, 0.2% gelatin, 0.05% sodium azide.
PurityPurified by Protein G affinity chromatography.
ImmunogenSynthetic peptide corresponding to aa706-728 of human TLR7 (KLH coupled).
SpecificityRecognizes human TLR7 (Toll Like Receptor 7). Species Crossreactivity: Human and mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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