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You are here:Home » Antibodies » Abs to Toll Like Receptors (TLR) » Anti -TLR12 (Toll-like Receptor 12, Gm1365)

Anti -TLR12 (Toll-like Receptor 12, Gm1365)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Ascites B
The Toll-like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules (1). The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition (2).  TLR12 has been cloned that displays a distinct pattern of expression in macrophages and liver, kidney, and bladder epithelial cells. TLR12 does not respond to known TLR ligands.
Catalog #T8051-21
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1:1000
Optimal dilutions to be determined by the researcher.
Positive ControlTransfected cell lysate
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgM
Clone No11E379
HostMouse
SourceMouse
ConcentrationNot determined.
FormSupplied as a liquid in PBS, 0.2% gelatin, 0.05% sodium azide.
PurityAscites
ImmunogenSynthetic peptide corresponding to aa791-806 (LGLRLCLPERDFEPGK) of mouse TLR12; GenBank no ref NP_991392.1|.
SpecificityRecognizes mouse TLR12.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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