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You are here:Home » Antibodies » Abs to Topoisomerases » Anti -Topoisomerase II (DNA) beta (TOP IIB, Top2 beta, Antigen MLAA 44, U937-associated Antigen)

Anti -Topoisomerase II (DNA) beta (TOP IIB, Top2 beta, Antigen MLAA 44, U937-associated
Antigen)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified IH
Topoisomerase II beta plays important roles in synthesis and transcription of DNA as well as chromosomal segregation during mitosis. It is present ubiquitously in normal cells and is unregulated in tumors and proliferating cells. Topoisomerase II beta is also implicated in drug resistance of tumor cells.
Catalog #T8065-21E
ApplicationsSuitable for use in Immunohistochemistry. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Positive Control Tonsil
Cellular Localization Nuclear
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20°C. Aliquots are stable for at least 3 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid in 10mM PBS, BSA. pH 7.4, 0.1% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenCorresponding to aa 300 of the C-terminus of human Topoisomerase II beta protein.
SpecificityDetects a band at approximately 300kD.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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