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You are here:Home » Antibodies » Abs to Signal Transduction » Anti -TRAF Interacting Protein TANK (TANK, I TRAF, ITRAF, I-TRAF, TRAF Family Member-associated NF kappa B Activator, TRAF Family Member-associated NFkB Activator, TRAF-interacting Protein, TRAF-interacting Protein TANK Isoform a, TRAF-interacting Protein TANK

Anti -TRAF Interacting Protein TANK (TANK, I TRAF, ITRAF, I-TRAF, TRAF Family
Member-associated NF kappa B Activator, TRAF Family Member-associated NFkB Activator,
TRAF-interacting Protein, TRAF-interacting Protein TANK Isoform a, TRAF-interacting
Protein TANK

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum B IP IH
The TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce signals from members of the tumor necrosis factor receptor (TNFR) superfamily. TANK:I-TRAF (TRAF family member associated NF-kB activator:TRAF-interacting protein) that was first defined as a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction (reviewed in Bonif, 2006). TANK:I-TRAF is thought to inhibit TRAF function by sequestering the TRAFs in the cytoplasm, thereby blocking their recruitment to the TNFR. TANK:I-TRAF has also been shown to bind to other proteins in the NF-kB signaling pathway, including NEMO. However, the role and different functions of TANK:I-TRAF in NF-kB signaling pathways remains to be fully elucidated. Recognizes TANK:I-TRAF, human TANK:I-TRAF is a 425aa protein.
Catalog #T8171-75C
ApplicationsSuitable for use in Western Blot, Immunohistochemistry and Immunoprecipitation. Other applications not tested.
Recommended DilutionWestern Blot: 1:1000-1:2000
Immunohistochemistry (formalin fixed paraffin embedded): 1:1000-1:5000
Immunoprecipitation: 1:50-1:200
Immunohistochemistry: Frozen
Optimal dilutions to be determined by the researcher.
Positive ControlLymphatic tissues, many cancer cell lines
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationNot determined.
FormSupplied as a liquid, 0.05% sodium azide.
PuritySerum
ImmunogenSynthetic peptide corresponding to aa346-367 (DPSDAPFPSLDSPGKAIRGPQQ) of human ITRAFn, GeneBank no. AAC50681.1.
SpecificityRecognizes human TANK/I-TRAF. Species sequence homology: mouse, rat, bovine.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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