Anti -TRAF Interacting Protein TANK (TANK, I TRAF, ITRAF, I-TRAF, TRAF Family
Member-associated NF kappa B Activator, TRAF Family Member-associated NFkB Activator,
TRAF-interacting Protein, TRAF-interacting Protein TANK Isoform a, TRAF-interacting
Protein TANK
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Serum |
B IP IH |
|
| The TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce signals from members of the tumor necrosis factor receptor (TNFR) superfamily. TANK:I-TRAF (TRAF family member associated NF-kB activator:TRAF-interacting protein) that was first defined as a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction (reviewed in Bonif, 2006). TANK:I-TRAF is thought to inhibit TRAF function by sequestering the TRAFs in the cytoplasm, thereby blocking their recruitment to the TNFR. TANK:I-TRAF has also been shown to bind to other proteins in the NF-kB signaling pathway, including NEMO. However, the role and different functions of TANK:I-TRAF in NF-kB signaling pathways remains to be fully elucidated. Recognizes TANK:I-TRAF, human TANK:I-TRAF is a 425aa protein. | | | Catalog # | T8171-75C | | Applications | Suitable for use in Western Blot, Immunohistochemistry and Immunoprecipitation. Other applications not tested. | | Recommended Dilution | Western Blot: 1:1000-1:2000 | | Immunohistochemistry (formalin fixed paraffin embedded): 1:1000-1:5000 | | Immunoprecipitation: 1:50-1:200 | | Immunohistochemistry: Frozen | | Optimal dilutions to be determined by the researcher. | | Positive Control | Lymphatic tissues, many cancer cell lines | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | Not determined. | | Form | Supplied as a liquid, 0.05% sodium azide. | | Purity | Serum | | Immunogen | Synthetic peptide corresponding to aa346-367 (DPSDAPFPSLDSPGKAIRGPQQ) of human ITRAFn, GeneBank no. AAC50681.1. | | Specificity | Recognizes human TANK/I-TRAF. Species sequence homology: mouse, rat, bovine. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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