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Anti -TRAF1 (TNF Receptor-associated Factor 1, 4732496E14Rik)
Anti -TRAF1 (TNF Receptor-associated Factor 1, 4732496E14Rik)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Serum |
B IP IH |
|
| The TRAF (TNF receptor-associated factor) family is a group of adapter proteins (TRAFs 1-6) that link a wide variety of cell surface receptors to diverse signaling cascades leading to the activation of NF-kB and mitogen-activated protein kinases (reviewed in Chung et al, 2002). TRAFs are major signal transducers for both the TNF and IL- 1:TLR receptor superfamilies and collectively play important functions in both adaptive and innate immunity. The carboxy-terminal region of TRAFs is required for self-association and interaction with receptor cytoplasmic domains following ligand-induced oligomerization. TRAFs interact with a variety of proteins that regulate receptor-induced cell death or survival, and TRAF-mediated signaling can promote cell survival or interfere with death receptor-induced apoptosis. Recognizes TRAF1; mouse TRAF1 is a 409aa protein. | | | Catalog # | T8171-91M | | Applications | Suitable for use in Western Blot, Immunohistochemistry and Immunoprecipitation. Other applications not tested. | | Recommended Dilution | Western Blot: 1:1000-1:2000 | | Immunohistochemistry (formalin fixed paraffin embedded): 1:1000-1:5000 | | Immunoprecipitation: 1:50-1:200 | | Immunohistochemistry: Frozen | | Optimal dilutions to be determined by the researcher. | | Positive Control | Spleen, lymphoid, many cancer cell lines | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Mouse | | Concentration | Not determined. | | Form | Supplied as a liquid, 0.05% sodium azide. | | Purity | Serum | | Immunogen | Synthetic peptide corresponding to aa51-69 (CRADNLHPVSPGSPLTQEK) of mouse TRAF1, GenBank no. NP_033447.2. | | Specificity | Recognizes mouse TRAF1. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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