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Anti -TRAF2 Binding Protein (TRAF2-binding Protein, T2BP, Putative MAPK-activating Protein PM14, Putative NF-kappa-B-activating Protein 20, TRAF-interacting Protein with Forkhead-associated Domain, TRAF-interacting Protein with FHA Domain-containing Protein A,
Anti -TRAF2 Binding Protein (TRAF2-binding Protein, T2BP, Putative MAPK-activating Protein
PM14, Putative NF-kappa-B-activating Protein 20, TRAF-interacting Protein with
Forkhead-associated Domain, TRAF-interacting Protein with FHA Domain-containing Protein A,
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Serum |
E |
|
| T2BP, a novel 184aa protein, is human homolog of mouse Tifa. It consists of a central phosphopeptide-binding FHA domain and a C-terminal TRAF6-binding motif. T2BP mediates multiple protein-protein interactions and plays a significant role in innate immunity, adaptive immunity and inflammation. It interacts with TRAF2 and is involved in TNF-mediated signaling. It induces oligomerization and polyubiquitination of TRAF6 leading to activation of TAK1 and IKK in a proteasome-independent mechanism and mediates NF-kappaB and JNK activation. It enhances IRAK1/TRAF6 interactions and mediates IL-1 signaling suggesting a novel regulation of innate immunity and inflammation. | | | Catalog # | T8171-96A | | Applications | Suitable for use in ELISA. Other applications not tested. | | Recommended Dilution | ELISA: 1:100-1:1000 | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | Not determined. | | Form | Supplied as a liquid. | | Purity | Serum | | Immunogen | Synthetic peptide corresponding to aa150-162 of human T2BP, TIFA. | | Specificity | Recognizes human TRAF2 Binding Protein. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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