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Anti -TRAF2 Binding Protein (TRAF2-binding Protein, T2BP, Putative MAPK-activating Protein PM14, Putative NF-kappa-B-activating Protein 20, TRAF-interacting Protein with Forkhead-associated Domain, TRAF-interacting Protein with FHA Domain-containing Protein A,
Anti -TRAF2 Binding Protein (TRAF2-binding Protein, T2BP, Putative MAPK-activating Protein
PM14, Putative NF-kappa-B-activating Protein 20, TRAF-interacting Protein with
Forkhead-associated Domain, TRAF-interacting Protein with FHA Domain-containing Protein A,
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Serum |
E |
|
| TIFA is a 184aa tumor necrosis factor receptor-associated factor 6 (TRAF)-interacting protein consisting of a forkhead-associated (FHA) domain that binds phosphothreonine, phosphoserine and a consensus TRAF6-binding motif. It activates NF-kB and c-JUN N-terminal kinase (JNK) and induces the oligomerization and polyubiquitination of TRAF6, which in turn activates TAK1 and IKK through a proteasome-independent mechanism. It acts as an adapter protein that links tumor necrosis factor receptor-associated factor 6 (TRAF6) to interleukin-1 (IL-1) receptor-associated kinase-1 (IRAK-1) in IL-1 receptor signaling. It is expressed widely in tumor cells. | | | Catalog # | T8171-96B | | Applications | Suitable for use in ELISA. Other applications not tested. | | Recommended Dilution | ELISA: 1:100-1:1000 | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | Not determined. | | Form | Supplied as a liquid, 0.025% sodium azide, 50% glycerol. | | Purity | Serum | | Immunogen | Synthetic peptide corresponding to aa167-182 (SLCSSQSSSPTEMDEN) of human TIFA. | | Specificity | Recognizes human TIFA. Species sequence homology: chimpanzee, monkey. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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