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You are here:Home » Antibodies » Abs to TRAF » Anti -TRAF2 Binding Protein (TRAF2-binding Protein, T2BP, Putative MAPK-activating Protein PM14, Putative NF-kappa-B-activating Protein 20, TRAF-interacting Protein with Forkhead-associated Domain, TRAF-interacting Protein with FHA Domain-containing Protein A,

Anti -TRAF2 Binding Protein (TRAF2-binding Protein, T2BP, Putative MAPK-activating Protein
PM14, Putative NF-kappa-B-activating Protein 20, TRAF-interacting Protein with
Forkhead-associated Domain, TRAF-interacting Protein with FHA Domain-containing Protein A,

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum E
TIFA is a 184aa tumor necrosis factor receptor-associated factor 6 (TRAF)-interacting protein consisting of a forkhead-associated (FHA) domain that binds phosphothreonine, phosphoserine and a consensus TRAF6-binding motif. It activates NF-kB and c-JUN N-terminal kinase (JNK) and induces the oligomerization and polyubiquitination of TRAF6, which in turn activates TAK1 and IKK through a proteasome-independent mechanism. It acts as an adapter protein that links tumor necrosis factor receptor-associated factor 6 (TRAF6) to interleukin-1 (IL-1) receptor-associated kinase-1 (IRAK-1) in IL-1 receptor signaling. It is expressed widely in tumor cells.
Catalog #T8171-96B
ApplicationsSuitable for use in ELISA. Other applications not tested.
Recommended DilutionELISA: 1:100-1:1000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationNot determined.
FormSupplied as a liquid, 0.025% sodium azide, 50% glycerol.
PuritySerum
ImmunogenSynthetic peptide corresponding to aa167-182 (SLCSSQSSSPTEMDEN) of human TIFA.
SpecificityRecognizes human TIFA. Species sequence homology: chimpanzee, monkey.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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