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Anti -TRAF3 (TNF Receptor-associated Factor 3, CAP1, CAP-1, CD40 Receptor-associated Factor 1, CRAF1, CD40-binding Protein, CD40BP, LMP1-associated Protein 1, LAP1)
Anti -TRAF3 (TNF Receptor-associated Factor 3, CAP1, CAP-1, CD40 Receptor-associated
Factor 1, CRAF1, CD40-binding Protein, CD40BP, LMP1-associated Protein 1, LAP1)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Serum |
B IP IH |
|
| The TRAF (TNF receptor-associated factor) family is a group of adapter proteins (TRAFs 1-6) that link a wide variety of cell surface receptors to diverse signaling cascades leading to the activation of NF-kB and mitogen-activated protein kinases (reviewed in Chung et al, 2002). TRAFs are major signal transducers for both the TNF and IL- 1:TLR receptor superfamilies and collectively play important functions in both adaptive and innate immunity. The carboxy-terminal region of TRAFs is required for self-association and interaction with receptor cytoplasmic domains following ligand-induced oligomerization. TRAFs interact with a variety of proteins that regulate receptor-induced cell death or survival, and TRAF-mediated signaling can promote cell survival or interfere with death receptor-induced apoptosis. | | | Catalog # | T8172-21A | | Applications | Suitable for use in Western Blot, Immunohistochemistry and Immunoprecipitation. Other applications not tested. | | Recommended Dilution | Western Blot: 1:1000-1:2000 | | Immunohistochemistry (formalin fixed paraffin embedded): 1:1000-1:5000 | | Immunoprecipitation: 1:50-1:200 | | Immunohistochemistry: Frozen | | Optimal dilutions to be determined by the researcher. | | Positive Control | Spleen, lymphoid, CA cell lines | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | Not determined. | | Form | Supplied as a liquid, 0.05% sodium azide. | | Purity | Serum | | Immunogen | Recombinant corresponding to protein fragment corresponding to the cytoplasmic end of human TRAF3 (aa341-568), GenBank no. GenBank no. gi|22027616|ref|NP_003291.2|. | | Specificity | Recognizes human TRAF3. Species Crossreactivity: gerbil, mouse, rat. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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