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Abs to Transcription Factors, Zinc (Ring) Finger
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Anti -TRAF6 (TNF Receptor-associated Factor 6, E3 Ubiquitin-protein Ligase TRAF6, Interleukin-1 Signal Transducer, MGC:3310, RING Finger Protein 85, RNF85)
Anti -TRAF6 (TNF Receptor-associated Factor 6, E3 Ubiquitin-protein Ligase TRAF6,
Interleukin-1 Signal Transducer, MGC:3310, RING Finger Protein 85, RNF85)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
B IH IC IF |
|
| Signals from the IL-1 receptor (IL-1R)/Toll-like receptor (TLR) and TNF receptor (TNFR) superfamilies are critical for regulating the function of antigen-presenting cells. Signals transduced by these molecules lead to increased expression and activation of transcription factors such as NF-kB. TNF receptor-associated factor 6 (TRAF6) is unique in that it is a signaling adapter molecule common to both families. TRAF6 is important in cytokine production, dendritic cell (DC) maturation, and the T cell stimulatory capacity of DCs in response to TLR and CD40 ligands. It can be activated in the IL-1R/TLR signaling pathway by IL-1 receptor-associated kinase 1 (IRAK-1) or by other TLR adaptor molecules such as TRIF. Also, it has been shown that TRAF6 can interact directly with TNFR family members CD40 and RANK. | | | Catalog # | T8172-60B | | Applications | Suitable for use in Western Blot, Immunocytochemistry, Immunofluorescence and Immunohistochemistry. Other applications not tested. | | Recommended Dilution | Western Blot: 1:500-1:3000 | | Immunohistochemistry (Formalin fixed paraffin embedded): 10ug/ml | | Immunofluorescence: 1:100-1:200 | | Immunocytochemistry: 1:100-1:200 | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Host | Rabbit | | Source | Human | | Concentration | ~1mg/ml | | Form | Supplied as a liquid in 0.1M Tris-glycine, pH 7, 0.01% thimerosal, 10% glycerol. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Recombinant corresponding to aa194-378 of human TRAF6. | | Specificity | Recognizes human TRAF6. Species sequence homology: bovine (82%), porcine (83%) and monkey (97%). | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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