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You are here:Home » Antibodies » Abs to Growth Factors, Cytokines » Anti -Transforming Growth Factor beta 1 (TGFb1, TGF-beta-1, TGFB1, TGFB)

Anti -Transforming Growth Factor beta 1 (TGFb1, TGF-beta-1, TGFB1, TGFB)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B IH
TGF-beta1 is a multifunctional protein that controls proliferation, differentiation and other functions in a wide range of cell types and both positively and negatively regulates many other growth factors. TGF-beta1 also plays an important role in bone remodelling through stimulation of oesteoblastic bone formation causing chemotaxis, proliferation and differentiation in committed osteoblasts. TGFB1 is synthesized by many cells and have specific receptors for it, and it is highly expressed in bone. Defects in TGFB1 are the cause of Camurati-Engelmann disease (CED), also known as progressive diaphyseal dysplasia 1 (DPD1).
Catalog #T8250-14F
ApplicationsSuitable for use in ELISA, Immunohistochemistry and Western Blot. Other applications not tested.
Recommended DilutionELISA: 1:2000-1:10,000
Western Blot: 1:200-1:1000
Immunohistochemistry (paraffin): 5ug/ml. Requires antigen retrieval using heat treatment for 20 minutes prior to staining of paraffin sections. 0.01M sodium citrate buffer, pH 6.0 is recommended for this purpose.
Optimal dilutions to be determined by the researcher.
Recommended Positive Control TissueHuman spleen
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in PBS, pH 7.2, 0.01% sodium azide.
PurityPurified by affinity chromatography.
ImmunogenA synthetic peptide corresponding to aa286-293 of the human TGF-beta precursor protein.
SpecificityRecognizes human TGF beta. Species crossreactivity: mammals
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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