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Anti -Transforming Growth Factor beta 1 (TGFb1, TGF-beta-1, TGFB1, TGFB)
Anti -Transforming Growth Factor beta 1 (TGFb1, TGF-beta-1, TGFB1, TGFB)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
E B IH |
|
| TGF-beta1 is a multifunctional protein that controls proliferation, differentiation and other functions in a wide range of cell types and both positively and negatively regulates many other growth factors. TGF-beta1 also plays an important role in bone remodelling through stimulation of oesteoblastic bone formation causing chemotaxis, proliferation and differentiation in committed osteoblasts. TGFB1 is synthesized by many cells and have specific receptors for it, and it is highly expressed in bone. Defects in TGFB1 are the cause of Camurati-Engelmann disease (CED), also known as progressive diaphyseal dysplasia 1 (DPD1). | | | Catalog # | T8250-14F | | Applications | Suitable for use in ELISA, Immunohistochemistry and Western Blot. Other applications not tested. | | Recommended Dilution | ELISA: 1:2000-1:10,000 | | Western Blot: 1:200-1:1000 | | Immunohistochemistry (paraffin): 5ug/ml. Requires antigen retrieval using heat treatment for 20 minutes prior to staining of paraffin sections. 0.01M sodium citrate buffer, pH 6.0 is recommended for this purpose. | | Optimal dilutions to be determined by the researcher. | | Recommended Positive Control Tissue | Human spleen | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | ~0.5mg/ml | | Form | Supplied as a liquid in PBS, pH 7.2, 0.01% sodium azide. | | Purity | Purified by affinity chromatography. | | Immunogen | A synthetic peptide corresponding to aa286-293 of the human TGF-beta precursor protein. | | Specificity | Recognizes human TGF beta. Species crossreactivity: mammals | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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