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You are here:Home » Growth Factors, Cytokines » Growth Factors-TGF » Transforming Growth Factor beta 3, Recombinant, Human (TGFb3)

Transforming Growth Factor beta 3, Recombinant, Human (TGFb3)

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Specifications

Transforming growth factor-betas (TGF betas) are multifunctional peptides that regulate growth and differentiation in a variety of cells. The transforming growth factor beta (TGF-beta) family of growth modulators play critical roles in tissue development and maintenance. Recent data suggest that individual TGF-beta isoforms (TGF-beta 1, -beta 2 and -beta 3) have overlapping yet distinct biological actions and target cell specificities, both in developing and adult tissues Transforming growth factor (TGF) beta 3 is a new isoform of the TGF beta superfamily and is presumed to play an important role in wound repair and scarring. TGF-beta 3 is believed to be involved in osteoblast proliferation, chemotaxis, and collagen synthesis.
Catalog #T8250-45A
Biological Activity TGF-beta 3 is fully biologically active when compared to standard. The ED50 as determined by the cell toxicity assay using the WHO Standard 98/608 as a direct comparison is < 0.05ng/ml, corresponding to a Specific Activity of 12.5x106IU/mg.
AA SequenceALDTNYCFRN LEENCCVRPL YIDFRQDLGW KWVHEPKGYY ANFCSGPCPY LRSADTTHST VLGLYNTLNP EASASPCCVP QDLEPLTILY YVGRTPKVEQ LSNMVVKSCK CS
Storage and StabilityMay be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight25.5kD
SourceRecombinant, human, E. coli
Purity95% as determined by RP-HPLC; Reducing and non-reducing SDS-PAGE.. Endotoxin: 0.1EU/ug (LAL)
Concentration~0.25mg/ml
FormSupplied as a liquid in 20% Ethanol and 0.12% Acetic acid.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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